A gold color metal and enamel device 1 3/16 inches (3.02 cm) in height overall consisting of a gold disc, the upper half edged by six vertical gold rays, three left and three right, and the lower half consisting of three horizontal wavy areas blue, gold and blue; surmounting the disc throughout a vertical maroon "Magari-yari" (a Japanese pole arm), the tip extending between and beyond the rays and below the perimeter in base, the pole arm entwined by a green serpent and surmounted at center by a white crucible bearing a red Greek cross.
Maroon and white are the colors used for the Army Medical Department and the serpent and pole arm allude to the staff of Aesculapius. The pole arm from the statue on Honshu, Japan, of Bishamon, mythological God of War and Victory, refers to the unit's activation in Japan. The upper portion of the disc represents the sun, and the lower portion alludes to water, both symbolic of therapy. The disc also simulates a wheel and denotes mobility. The crucible, a tool of metallurgists (steel) refers to Gary, Indiana, present home of the organization, represented by the red cross.
The distinctive unit insignia was originally approved for the 395th Evacuation Hospital on 18 February 1971. It was redesignated for the 395th Combat Support Hospital on 9 November 1976.